GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12206610 | 1 | rs12206610 | chr6:166016800 | PDE10A | chr6:165740779-166075584:- | -0.18 | -4.26 | 2.24E-5 | Spherical equivalent (joint main effects and education interaction) |
| BRCA | cis | rs12196860 | 1 | rs12206920 | chr6:55966027 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12207120 | chr6:55936134 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.99 | 4.96E-12 | Psychosis (atypical) |
| BRCA | cis | rs1577917 | 1 | rs12207305 | chr6:86723502 | SNHG5 | chr6:86386726-86388451:- | -0.58 | -18.36 | 1.31E-65 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12207610 | chr6:86688016 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -17.75 | 6.04E-62 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12207665 | chr6:55991330 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.98 | 5.28E-12 | Psychosis (atypical) |
| BRCA | cis | rs12524865 | 1 | rs12207772 | chr6:134189834 | TCF21 | chr6:134210259-134219157:+ | 0.16 | 4.27 | 2.1E-5 | Coronary heart disease |
| BRCA | cis | rs12216499 | 1 | rs12207795 | chr6:159366261 | RSPH3 | chr6:159398268-159421198:- | 0.19 | 3.52 | 0.000448 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs1577917 | 1 | rs12208493 | chr6:86662267 | SNHG5 | chr6:86386726-86388451:- | -0.61 | -18.94 | 3.26E-69 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12208500 | chr6:55933259 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12208615 | chr6:55933489 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12208823 | chr6:55966902 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.81 | 1.58E-11 | Psychosis (atypical) |
| BRCA | cis | rs12216499 | 1 | rs12208892 | chr6:159371192 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.71 | 0.000216 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs12208901 | chr6:159371238 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.71 | 0.000216 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs1577917 | 1 | rs12209127 | chr6:86724427 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -18.36 | 1.26E-65 | Response to antipsychotic treatment |